Publications

 

Frimodt-Møller J, Campion C, Nielsen PE, Løbner-Olesen A. Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope.  Curr Genet. 2021 Nov 8.  Review. Online ahead of print 

Vestergaard, M.; Skive, B.; Domraceva, I.; Ingmer, H.; Franzyk, H. Peptide/β-peptoid hybrids with activity against vancomycin-resistant enterococci: Influence of hydrophobicity and structural features on antibacterial and hemolytic properties. Int. J. Mol. Sci. 2021, 22, 5617.

Frederiksen, N.; Loukas, S.; Mudaliar, C.; Domraceva, I.; Kreichberga, A.; Pugovics, O.; Zabicka, D.; Tomczak, M.; Wygoda, W.; Björkling, F.; Franzyk, H. Peptide/β-Peptoid Hybrids with ultrashort PEG-like moieties: Effects on hydrophobicity, antibacterial and hemolytic properties. Int. J. Mol. Sci. 2021, 22, 7041.

Wester, A.; Hansen, A. M.; Hansen, P. R.; Franzyk, H. Perfluoro-tert-butanol for selective on-resin detritylation: A mild alternative to traditionally used methods. Amino Acids 2021, 53, 1455-1466.

Wester, A.;  Björkling, F.; Franzyk, H. 1-H-triazole-1-[N,N'-bis(tert-butoxycarbonyl)] carboxamidine: A versatile reagent for efficient solution-phase and on-resin guanidinylation. J. Org. Chem. 2021, 86, 14371-14380.

Frimodt-Møller J, Koulouktsis A, Charbon G, Otterlei M, Nielsen PE, Løbner-Olesen A. Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli.  . Mol Ther Nucleic Acids. 2021;25:444-454. doi: 10.1016/j.omtn.2021.06.009.

Campion C, Charbon G, Thomsen TT, Nielsen PE, Løbner-Olesen A. Antisense inhibition of the Escherichia coli NrdAB aerobic ribonucleotide reductase is bactericidal due to induction of DNA strand breaks.. J Antimicrob Chemother. 2021;76:2802-2814. doi: 10.1093/jac/dkab305.

Mood EH, Goltermann L, Brolin C, Cavaco LM, Nejad AJ, Yavari N, Frederiksen N, Franzyk H, Nielsen PE. Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic. . ACS Infect Dis. 2021;7:2152-2163. doi: 10.1021/acsinfecdis.1c00147

Ashif Y. ShaikhFredrik BjörklingPeter E. Nielsen,  Henrik Franzyk. Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers Eur. J. Org. Chem. 2021, 27922801

Nejad AJ, Shahrokhi N, Nielsen PE. Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials. Biomedicines. 2021; 9(4):429.

Yavari N, Goltermann L, Nielsen PE. Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA.  ACS Chem Biol. 2021 Mar 19;16(3):471-479.

Charbon G, Haugan MS, Frimodt-Møller N, Løbner-Olesen A. 2020. Counting Replication Origins to Measure Growth of Pathogens. Antibiotics (Basel). 9, 239. doi: 10.3390/antibiotics9050239.  Free PMC article.

Ebbensgaard, A., Løbner-Olesen, A., and Frimodt-Møller, J. 2020. The role of efflux pumps in the transition from low-level to clinical antibiotic resistance. Antibiotics, 9, 855. doi: 10.3390/antibiotics9120855

Jensen, S. K.; Thomsen, T. T.; Oddo, A.; Franzyk, H.; Anders Løbner-Olesen, A.; Hansen, P. R. Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position. Int. J. Mol. Sci. 2020, 21, 5829 .

Frederiksen, N; Hansen, P. R.; Zabicka, D.; Tomczak, M.; Urbas, M.; Domraceva, I.; Björkling, F.; Franzyk, H. Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity. ChemMedChem (Nordic Medicinal Chemistry) 2020, 15, 2544-2561.                                      

Hansen, A. M.; Shaikh, A. Y.; Franzyk, H. 2020. Facile preparation of PNA-peptide conjugates with polar maleimido-thioether linkage. In: Nielsen, P. E. (Ed) Peptides Nucleic Acids: Methods and Protocols (3rd Edition). Methods Mol. Biol. (Clifton, N.J.), Springer (New York, NY) vol. 2105, pp. 1-16.

Shaikh, A. Y.; Hansen, A. M.; Franzyk, H. 2020. Fmoc-based assembly of PNA oligomers: manual and microwave-assisted automated synthesis. In: Nielsen, P. E. (Ed) Peptides Nucleic Acids: Methods and Protocols (3rd Edition). Methods Mol. Biol. (Clifton, N.J.), Springer (New York, NY) (Clifton, N.J.) vol. 2105, pp. 97-118.

Frederiksen N,  Hansen PR,  Björkling F, Franzyk H. Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity. Molecules 2019, 24, 4429; doi:10.3390/molecules24244429

Goltermann L, Yavari N, Zhang M, Ghosal A, Nielsen PE. PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane. Front Microbiol. 2019 May 24;10:1032.

Hansen AM, Bonke G, Hogendorf WFJ, Björkling F, Nielsen J, Kongstad KT, Zabicka D, Tomczak M, Urbas M, Nielsen PE, Franzyk H. Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. Eur J Med Chem. 2019 Apr 15;168:134-145.