Publications
Charbon G, Mendoza-Chamizo B, Campion C, Li X, Jensen P, Frimodt-Møller J, ... Løbner-Olesen A. (2021). Energy Starvation Induces a Cell Cycle Arrest in Escherichia coli by Triggering Degradation of the DnaA Initiator Protein. Frontiers in Molecular Biosciences, doi: 10.3389/fmolb.2021.629953
Frederiksen N, Louka S, Mudaliar C, Domraceva I, Kreicberga A, Pugovics O, ... Franzyk H. (2021). Peptide/β-Peptoid Hybrids with Ultrashort PEG-Like Moieties: Effects on Hydrophobicity, Antibacterial Activity and Hemolytic Properties. International journal of molecular sciences, 22(13), doi: 10.3390/ijms22137041
Frimodt-Møller J, Løbner-Olesen A. (2019). Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?. Trends in Microbiology, (4), doi: 10.1016/j.tim.2019.01.005
Frimodt-Møller J, Campion C, Nielsen PE, Løbner-Olesen A. (2022). Translocation of non-lytic antimicrobial peptides and bacteria penetrating peptides across the inner membrane of the bacterial envelope. Current genetics, 68(1), pp. 83-90. doi: 10.1007/s00294-021-01217-9
Goltermann L, Nielsen PE. (2020). PNA Antisense Targeting in Bacteria: Determination of Antibacterial Activity (MIC) of PNA-Peptide Conjugates. Methods in molecular biology (Clifton, N.J.), 2105, pp. 231-239. doi: 10.1007/978-1-0716-0243-0_14
Lim EWK, Brolin C, Nielsen PE. (2020). Near-Infrared In Vivo Whole-Body Fluorescence Imaging of PNA. Methods in molecular biology (Clifton, N.J.), 2105, pp. 251-260. doi: 10.1007/978-1-0716-0243-0_16
Thomsen TT, Mendel HC, Al-Mansour W, Oddo A, Løbner-Olesen A, Hansen PR. (2020). Analogues of a Cyclic Antimicrobial Peptide with a Flexible Linker Show Promising Activity against Pseudomonas aeruginosa and Staphylococcus aureus. Antibiotics (Basel, Switzerland), 9(7), doi: 10.3390/antibiotics9070366
Vestergaard, M.; Skive, B.; Domraceva, I.; Ingmer, H.; Franzyk, H. Peptide/β-peptoid hybrids with activity against vancomycin-resistant enterococci: Influence of hydrophobicity and structural features on antibacterial and hemolytic properties. Int. J. Mol. Sci. 2021, 22, 5617.
Frederiksen, N.; Loukas, S.; Mudaliar, C.; Domraceva, I.; Kreichberga, A.; Pugovics, O.; Zabicka, D.; Tomczak, M.; Wygoda, W.; Björkling, F.; Franzyk, H. Peptide/β-Peptoid Hybrids with ultrashort PEG-like moieties: Effects on hydrophobicity, antibacterial and hemolytic properties. Int. J. Mol. Sci. 2021, 22, 7041.
Wester, A.; Hansen, A. M.; Hansen, P. R.; Franzyk, H. Perfluoro-tert-butanol for selective on-resin detritylation: A mild alternative to traditionally used methods. Amino Acids 2021, 53, 1455-1466.
Wester, A.; Björkling, F.; Franzyk, H. 1-H-triazole-1-[N,N'-bis(tert-butoxycarbonyl)] carboxamidine: A versatile reagent for efficient solution-phase and on-resin guanidinylation. J. Org. Chem. 2021, 86, 14371-14380.
Frimodt-Møller J, Koulouktsis A, Charbon G, Otterlei M, Nielsen PE, Løbner-Olesen A. Activating the Cpx response induces tolerance to antisense PNA delivered by an arginine-rich peptide in Escherichia coli. . Mol Ther Nucleic Acids. 2021;25:444-454. doi: 10.1016/j.omtn.2021.06.009.
Campion C, Charbon G, Thomsen TT, Nielsen PE, Løbner-Olesen A. Antisense inhibition of the Escherichia coli NrdAB aerobic ribonucleotide reductase is bactericidal due to induction of DNA strand breaks.. J Antimicrob Chemother. 2021;76:2802-2814. doi: 10.1093/jac/dkab305.
Mood EH, Goltermann L, Brolin C, Cavaco LM, Nejad AJ, Yavari N, Frederiksen N, Franzyk H, Nielsen PE. Antibiotic Potentiation in Multidrug-Resistant Gram-Negative Pathogenic Bacteria by a Synthetic Peptidomimetic. . ACS Infect Dis. 2021;7:2152-2163. doi: 10.1021/acsinfecdis.1c00147
Ashif Y. Shaikh, Fredrik Björkling, Peter E. Nielsen, Henrik Franzyk. Optimized Synthesis of Fmoc/Boc-Protected PNA Monomers and their Assembly into PNA Oligomers. Eur. J. Org. Chem. 2021, 2792–2801
Nejad AJ, Shahrokhi N, Nielsen PE. Targeting of the Essential acpP, ftsZ, and rne Genes in Carbapenem-Resistant Acinetobacter baumannii by Antisense PNA Precision Antibacterials. Biomedicines. 2021; 9(4):429.
Yavari N, Goltermann L, Nielsen PE. Uptake, Stability, and Activity of Antisense Anti-acpP PNA-Peptide Conjugates in Escherichia coli and the Role of SbmA. ACS Chem Biol. 2021 Mar 19;16(3):471-479.
Charbon G, Haugan MS, Frimodt-Møller N, Løbner-Olesen A. 2020. Counting Replication Origins to Measure Growth of Pathogens. Antibiotics (Basel). 9, 239. doi: 10.3390/antibiotics9050239. Free PMC article.
Ebbensgaard, A., Løbner-Olesen, A., and Frimodt-Møller, J. 2020. The role of efflux pumps in the transition from low-level to clinical antibiotic resistance. Antibiotics, 9, 855. doi: 10.3390/antibiotics9120855
Jensen, S. K.; Thomsen, T. T.; Oddo, A.; Franzyk, H.; Anders Løbner-Olesen, A.; Hansen, P. R. Novel Cyclic Lipopeptide Antibiotics: Effects of Acyl Chain Length and Position. Int. J. Mol. Sci. 2020, 21, 5829 .
Frederiksen, N; Hansen, P. R.; Zabicka, D.; Tomczak, M.; Urbas, M.; Domraceva, I.; Björkling, F.; Franzyk, H. Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity on Antibacterial Activity and Cell Selectivity. ChemMedChem (Nordic Medicinal Chemistry) 2020, 15, 2544-2561.
Hansen, A. M.; Shaikh, A. Y.; Franzyk, H. 2020. Facile preparation of PNA-peptide conjugates with polar maleimido-thioether linkage. In: Nielsen, P. E. (Ed) Peptides Nucleic Acids: Methods and Protocols (3rd Edition). Methods Mol. Biol. (Clifton, N.J.), Springer (New York, NY) vol. 2105, pp. 1-16.
Shaikh, A. Y.; Hansen, A. M.; Franzyk, H. 2020. Fmoc-based assembly of PNA oligomers: manual and microwave-assisted automated synthesis. In: Nielsen, P. E. (Ed) Peptides Nucleic Acids: Methods and Protocols (3rd Edition). Methods Mol. Biol. (Clifton, N.J.), Springer (New York, NY) (Clifton, N.J.) vol. 2105, pp. 97-118.
Frederiksen N, Hansen PR, Björkling F, Franzyk H. Peptide/Peptoid Hybrid Oligomers: The Influence of Hydrophobicity and Relative Side-Chain Length on Antibacterial Activity and Cell Selectivity. Molecules 2019, 24, 4429; doi:10.3390/molecules24244429
Goltermann L, Yavari N, Zhang M, Ghosal A, Nielsen PE. PNA Length Restriction of Antibacterial Activity of Peptide-PNA Conjugates in Escherichia coli Through Effects of the Inner Membrane. Front Microbiol. 2019 May 24;10:1032.
Hansen AM, Bonke G, Hogendorf WFJ, Björkling F, Nielsen J, Kongstad KT, Zabicka D, Tomczak M, Urbas M, Nielsen PE, Franzyk H. Microwave-assisted solid-phase synthesis of antisense acpP peptide nucleic acid-peptide conjugates active against colistin- and tigecycline-resistant E. coli and K. pneumoniae. Eur J Med Chem. 2019 Apr 15;168:134-145.
Montagner G, Bezzerri V, Cabrini G, Fabbri E, Borgatti M, Lampronti I, Finotti A, Nielsen PE, Gambari R. An antisense peptide nucleic acid against Pseudomonas aeruginosa inhibiting bacterial-induced inflammatory responses in the cystic fibrosis IB3-1 cellular model system. Int J Biol Macromol. 2017 Jun;99:492-498.
Carattoli A, E. Zankari, A. Garcìa-Fernandez, M. Volby Larsen, O. Lund, L. Villa, F.M. Aarestrup, H. Hasman. 2014. Antimicrob Agents Chemother. 58:3895-903.
Charbon, G., Bjørn, L., Chamizo, B.M., Frimodt-Møller, J., and Løbner-Olesen, A. 2014. Nucleic Acids Res.,42, 13228-13241.
Citterio, L.; Franzyk, H.; Palarasah, Y.; Andersen, T. E.; Mateiu, R. V.; Gram, L Res. Microbiol. 2016, 167, 72-82.
Frimodt-Møller, J., Charbon, G., Krogfelt, K.A., and Løbner-Olesen, A. 2015.. Front. Microbiol., 2015,
6,1011.
Ghosal, A. and P. E. Nielsen. 2012. Nucleic Acid Therapy 22:323-334.
Ghosal, A., A. Vitali, J. E. Stach, and P. E. Nielsen. 2012 ACS Chemical Biology 8:360-367.
Good L, Awasthi S.K., Dryselius R, Larsson O., Nielsen P.E. 2001 Nature. Biotechnol. 19, 360-4
Good L, Nielsen P.E. 1998 Nature Biotechnol. 16, 355-8
Hansen F, Johansen HK, Ostergaard C, Arpi M, Hansen DS, Littauer P, Holm A, Heltberg O, Schumacher H,Fuursted K, Lykke MA, Tønning B, Hammerum AM, Justesen US. 2014. Microb Drug Resist. 20:22-9.
Hansen F, Olsen SS, Heltberg O, Justesen US, Fuglsang-Damgaard D, Knudsen JD, Hammerum AM.Microb Drug Resist. 2014 20:316-24.
Hansen, A. M.; Seigan, G. B.; Larsen, C. J.; Yavari, N.; Nielsen, P. E.; Franzyk, H. Bioconjugate Chem. 2016, 27, 863-867.
Hasman H, Hammerum AM, Hansen F, Hendriksen RS, Olesen B, Agersø Y, Zankari E, Leekitcharoenphon P, Stegger M, Kaas RS, Cavaco LM, Hansen DS, Aarestrup FM, Skov RL. 2015 Euro Surveill. 10;20(49).
Hein-Kristensen, L.; Knapp, K.M.; Franzyk, H.; Gram, L. Res. Microbiol. 2013, 164, 933-940
Hertz, F.B. Budding, A.E., van der Lugt-Degen, A., Savelkoul, P.H., Løbner-Olesen, A., and Frimodt-Møller, N. 2015. Antimicrobial Agents and Chemotherapy, AAC01755-15
Hertz, F.B., Løbner-Olesen, A., and Frimodt-Møller, N. 2014. Antimicrobial Agents and Chemotherapy, 58,
6139-6144
Jahnsen, R. D.; Haney, E. F.; Franzyk, H.; Hancock, R. E. W. Chem. Biol. 2013, 20, 1286-1295.
Jahnsen, R. D.; Sandberg-Schaal, A.; Vissing, K. J.; Nielsen, H. M.; Frimodt-Møller, N.; Franzyk, H. J. Med. Chem. 2014, 57, 2864-2873.
Jahnsen, R. O.; Sandberg-Schaal, A.; Frimodt-Møller, N.; Nielsen, H. M.; Franzyk, H. Eur. J. Pharm. Biopharm. 2015, 95, 40-46.
Jakobsen, H., Bojer, M.S., Marinus, M.G., Struve, C., Krogfelt, K.A., and Løbner-Olesen, A. 2013. PLoS ONE, 8, e60519
Kjelstrup, S., Hansen, P.M.P., Thomsen, L.E., Hansen, P.R., and Løbner-Olesen, A. 2013. PLoS ONE, 8,
e722273
Marinus, M, Løbner-Olesen, A. 2014. DNA Methylation, EcoSal Plus 2014; doi:10.1128/ecosalplus.ESP-0003-2013
Nielsen, P. E. and D. H. Appella. 2014. Peptide Nucleic Acids. Springer-Verlag, Heidelberg.
Oddo, A., Thomas, T.T., Kjelstrup, S., Gorey, C., Franzyk, H., Frimodt-Møller, N., Løbner-Olesen, A., and
Hansen, P.R., 2016. Antimicrobial Agents and Chemotherapy, 60, 592-599
Paulander, W., Wang, Y., Folkesson, A., Charbon, G., Løbner-Olesen, A. and H. Ingmer. 2014, PLoS ONE, 9, e92231
Skovbakke, S. L.; Larsen, C. J.; Heegaard, P. M. H.; Moesby, L.; Franzyk, H. J. Med. Chem. 2015, 58, 801-813.
Thomsen, T., Mojsoska, B., Cruz, J., Donadio, S., Jenssen, H., Løbner-Olesen, A., and Rewitz, K. 2016.
Antimicrobial Agents and Chemotherapy, In Press, AAC02965-15
Vingsbo Lundberg C and Frimodt-Møller N. 2013. Int J Antimicrob Agents 42:272-275
Vingsbo Lundberg C, Vaara T, Frimodt-Møller N, Vaara M. 2010. J Antimicrob Chemother. 65:981-5.