About the center – University of Copenhagen

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About the center

Peptide Antibiotics against Resistant Bacterial Infections

In response to the critical and increasing worldwide threat to human health posed by emergence of bacterial resistance to currently used antibiotics, the overall aim of the center is to establish a discovery platform that focuses on peptide-based antibiotics by exploiting unleashed advantages of peptides that interact with the bacterial envelope. Discovery of leads, therapeutic strategies and antibiotic targets useful for treatment of multidrug-resistant Gram-negative infections, and elucidation of mechanism of action are core activities.

In particular, the antisense antibacterial concept and novel peptide carriers for efficient delivery of potential antibacterial compounds with inherently poor bacterial uptake will be explored. Peptide-based adjuvant antibiotics will be discovered and investigated as a means for circumventing resistance to current antibiotics and to sensibilize bacteria to antibiotics that they are inherently resistant to. Also, synergistic combinations representing a multimodal treatment regimen will be examined as an approach for reducing risk of resistance development.